Science

You Don’t Like Coffee but you need Caffeine: Here is the Solution

For many, coffee is a gastronomic delight. However, for others, it’s more of a syrup—a medicinal aid in facing the mornings, armed with numerous benefits, especially after a night of little or poor sleep. To the delight of the latter group, science brings some good news.

Unveiling the Potion for Daytime Drowsiness

After scrutinizing 14 clinical studies, a team of researchers identified three potentially potent medications capable of combating excessive daytime sleepiness: solriamfetol, armodafinil (armodafinil-modafinil), and pitolisant. Among these compounds, solriamfetol stood out as the most noteworthy, showing greater efficacy compared to the placebos administered in the study context.

Excessive Daytime Sleepiness and Sleep Apnea

Excessive daytime sleepiness (EDS) or hypersomnia is often associated with obstructive sleep apnea (OSA). Individuals with OSA tend to get less rest during the night due to minor sleep interruptions caused by respiratory issues. Currently, both solriamfetol and armodafinil are used in the treatment of EDS and OSA, though the primary treatment remains positive airway pressure masks (CPAP).

Analyzing Over 3,000 Patients

In their research, the study’s investigators analyzed a total of 14 clinical trials, encompassing a sample of 3,085 patients. The analysis concluded that all three mentioned compounds could combat EDS, though to varying degrees. Solriamfetol demonstrated a statistical advantage, showing the most significant difference compared to placebo results. However, both armodafinil and pitolisant also exhibited indications of a “probable” positive effect, at least concerning certain vigilance measures.

The Catch: Not Without Side Effects

The study also delved into the side effects of different treatments. Both armodafinil and solriamfetol presented effects that could be inconvenient, with armodafinil being more likely to lead patients to discontinue treatment. The study’s authors emphasize the need for further research in this regard, especially focused on the long-term effects of solriamfetol, with one concern being its potential impact on blood pressure.

Exploring Additional Applications

The authors note that these treatments could potentially aid in other issues, such as chronic fatigue syndrome and even the long-term effects of Covid. Dena Zeraatkar, a co-author of the study, expressed, “It would be interesting to see how effective these anti-fatigue medications are in treating related conditions like chronic fatigue syndrome or long Covid, now that we know they work for a similar condition.”

A Good Night’s Sleep

Sleep apnea isn’t the only factor stealing our sleep at night. Millions of people struggle to fall asleep, impacting their daily lives. While medications are often prescribed to improve sleep quality, there’s a documented trend of excessive consumption of these drugs.

This leads us to explore alternative methods to enhance our sleep quality, known as sleep hygiene. Practices such as maintaining regular schedules, exercising (not in the late hours before bedtime), or avoiding screens and other blue lights in the late hours of the day are common recommendations. Other common practices include relaxation exercises.

In the quest for a good night’s sleep, these revelations about medications offer a ray of hope. However, it’s crucial to balance the potential benefits with an understanding of possible side effects and the need for ongoing research. After all, a good night’s sleep is not just a luxury but a fundamental pillar of overall well-being. So, as we navigate the realm of sleep aid medications, let’s tread carefully and embrace a holistic approach to a restful night.

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